Measurement of Neutrophil Gelatinase-Associated Lipocalin Concentration in Canine Cerebrospinal Fluid and Serum and Its Involvement in Neuroinflammation.
Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein is involved in inflammation acts as an acute phase protein and chemokines as well as a regulator of iron homeostasis. NGAL has proved to be upregulated in experimental autoimmune encephalomyelitis (EAE) in mice. Increasing concentrations of NGAL in Ovine Serum the cerebrospinal fluid (CSF) and the expression in the central nervous system (CNS) have been described in human neuroinflammatory diseases such as multiple sclerosis and lupus, neuropsychiatric and bacterial meningitis. We aimed to investigate the involvement of NGAL in spontaneous nerve inflammation dog as an animal model of the potential immune-mediated neurological disorders. A commercially available enzyme-linked immunosorbent assay (ELISA) for the detection of NGAL dog CSF validated for use in dogs. Concentration in CSF and serum of patients suffering from steroid-responsive dog meningitis- arteriitis (SRMA), Meningoencephalitis of unknown...