Spontaneous benign prostatic hyperplasia in the beagle. Age-associated changes in serum hormone levels, and the morphology and secretory function of the canine prostate.

This paper is a cross-sectional study of spontaneous benign prostatic hyperplasia (BPH) in a single canine species. The effects of aging and hormonal changes in growth, histology and function of the prostate gland secretion of dogs studied in 42 male beagle dogs aged between 8 mo to 9 yrs. Beagle enlarged prostate for at least 6 years, whether normal or hyperplastic.

In contrast, prostate secretory function, determined Rabbit Serum by the volume of ejaculate and total protein ejaculation, decreased sharply after 4 years of age. growth and functional changes in the prostate reciprocal closely associated with a progressive increase in the incidence of BPH, which is already evident in some dogs at the age of two. By the age of simple decline in serum androgen levels with no apparent change in serum 17 beta-estradiol levels. 

This indicates that the growth and functional changes associated with the development of BPH and begins very early in life change reflects the sensitivity to androgens serum prostate or in response to a relative reduction in serum androgen to estrogen ratio.

Counterimmunoelectrophoresis (immunoelectroosmosis) and serum electrophoresis pattern in canine serological diagnosis of blastomycosis.

Counterimmunoelectrophoresis (CIEP) with Blastomyces and Histoplasma antigen used in serological study of 181 clinical dogs suspected to have blastomycosis and 8 dogs with confirmed blastomycosis or histoplasmosis. Thirteen of the 181 dogs, positive by CIEP, which euthanatized, and the diagnosis is confirmed by cultivation and / or microscopic detection of Blastomyces dermatitidis. Additional dog-positive CIEP confirmed by staining of aspiration collected in vivo. support radiography for diagnosis reported in four other dogs where histoplasmosis issued by negative CIEP with Histoplasma antigen. 

Antibodies originator may be lost during the course of the disease, as happened in the first dogs treated with amphotericin B, but not cured. This dog Rabbit Serum Albumin is returned from CIEP CIEP-negative-positive within 17 months of treatment (with a weak reaction after 10 months of treatment). CIEP-detectable antibody is present only in one dog without confirmation with histopathologic findings or cultivation among 24 well-documented cases and 181 total sera tested. 

The CIEP more sensitive and specific than the gel-diffusion precipitin test, eliminating problems that often affect anticomplementarity complement fixation test results with dog sera, and served well in detecting dogs with blastomycosis. Serum electrophoretic pattern of CIEP-positive dogs with blastomycosis showed a decrease in albumin and increased alpha 2- and often in beta and gamma-globulin, with a large reduction of the ratio of albumin / globulin.